
For teams working to self-host LLMs, inference at scale isn’t just about having powerful models for your own use case. It’s also about supporting those models with the right hardware.
That means getting the right GPU, in the right region, at the right price, and at the right time.
Make the wrong choices early on, and you could end up with underutilized resources, unexpected operational costs, or delayed deployments. This is especially common when buying or renting GPUs for on-prem LLM deployment. It requires higher upfront costs and longer lead times, and flexibility is limited compared to cloud-based options.
In this guide, we will cover:
Before we look at where to source GPUs, it’s important to understand what actually drives your GPU choice.
GPU memory (VRAM) determines how large a model you can serve and how long a context window you can support.
During inference, each new token stores intermediate results in memory (KV cache) so the LLM doesn’t have to recompute previous tokens. This caching mechanism drastically improves speed, but it also consumes a significant amount of memory.
The longer the context, the larger the KV cache grows. Since GPU memory is limited, the KV cache often becomes the bottleneck for running LLMs with long contexts.
If you don’t have enough VRAM, you might need to split the model across multiple GPUs using tensor parallelism or offload the KV cache elsewhere.
In short, VRAM = headroom. It gives you flexibility for longer prompts, more requests, and larger models without having to re-architect your setup.
When choosing GPUs, estimate how much memory your model actually needs. Add a buffer for KV cache growth and runtime overhead.
Performance determines how quickly your model can generate responses and how efficiently you’re using your GPUs.
There are many factors that can impact performance. Before buying or renting GPUs, focus on two key metrics:
Don’t rely solely on marketing numbers. Always benchmark your GPU to understand real-world performance and efficiency. I recommend llm-optimizer, an open-source tool that helps you benchmark and optimize any open LLMs on different GPUs.
When sourcing GPUs, two practical questions always come:
How much will it cost, and can you actually get one when you need it?
Here’s what you need to know:
For enterprise AI teams, a bigger challenge is what we call the GPU CAP Theorem: A GPU infrastructure cannot guarantee Control, on-demand Availability, and Price at the same time.

The key is to balance these three based on your workload patterns. Learn more about how to Beat the GPU CAP Theorem with Bento Inference Platform.
Lastly, check what software ecosystem your GPUs support.
NVIDIA GPUs still dominate for production inference due to their mature driver stack, better kernel fusion, and wide community support.
However, AMD is catching up fast with the ROCm ecosystem and cards like MI300X and MI355X, which already support many PyTorch and Hugging Face models.
If you plan to deploy across vendors, ideally, your inference stack should support both CUDA and ROCm environments to avoid vendor lock-in.
Now that you understand what drives GPU decisions, let’s look at where you can actually get GPUs.
Major cloud providers offer the fastest way to get started. You can spin up a GPU instance in minutes.
Popular options include AWS G5/G6/P4/P5, Azure NC/ND, and Google Cloud A2/A3 series. They cover a wide range of GPUs from both NVIDIA (e.g., T4, L4, A100, H100, H200) and AMD (e.g., MI250X, MI300X, MI355X).
Pros:
Cons:
Specialized GPU clouds, or NeoClouds, focus primarily on AI workloads. They often provide better price/performance and access to a wider variety of GPUs than hyperscalers.
Popular options include CoreWeave, Nebius, Vultr and Lambda.
Pros:
Cons:
Emerging decentralized networks let you rent compute from distributed GPU owners.
They’re experimental but increasingly popular for cost optimization.
Popular options include Vast.ai, SF Compute, and Salad.
Pros:
Cons:
Buying GPUs outright gives you full control over hardware and deployment.
You can source cards directly from NVIDIA and AMD, or through original equipment (OE) partners like Dell, GIGABYTE and HPE.
Pros:
Cons:
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Each sourcing model has its place. The key is to mix and match.
Running LLM inference in one region or on one cloud might seem simpler, until you hit a traffic surge, a GPU shortage, or a compliance issue.
That’s when teams realize why multi-cloud, cross-region or hybrid deployments are essential for scalable, cost-efficient, and reliable LLM inference.
Training happens in planned, predictable batches.
Inference workloads don’t. It happens with real users in real time, and it’s rarely steady.
A product launch, a marketing campaign, or even a viral post can flood your inference endpoints overnight. Demand can jump from near-idle to GPU-saturation in minutes.
Your compute capacity can max out at the worst possible time. Your carefully planned infrastructure can crumble under the load.
That’s why the smartest AI teams no longer rely on a single cloud or region. They spread their workloads across multiple places to have extra headroom.
When one region fills up, traffic simply reroutes to another. When a provider runs short on GPUs, requests overflow seamlessly elsewhere.
For LLMs that depend on high-end GPUs like NVIDIA H200 or AMD MI355X, this flexibility isn’t optional; it’s survival. These GPUs are expensive, scarce, and often back-ordered for months.
Multi-region setups let you keep serving when your competitor is waiting in line.
Regulatory and privacy rules are getting stricter every year.
Why? LLMs increasingly power applications that handle sensitive information, from AI agents to RAG systems.
In sectors like healthcare, finance, and government, enterprises running LLMs on customer or proprietary data must follow data residency laws. They are required to store and process data within specific borders (e.g, the EU’s GDPR).
A single global endpoint can quickly violate those requirements.
By contrast, a multi-cloud, cross-region architecture solves this elegantly:
This keeps data local and compliant, without sacrificing uptime or performance.
GPUs don’t cost the same everywhere, not even close.
Pricing varies by provider, region, and even availability zone.
Take Google Cloud’s a3-highgpu-1g instance (1×H100 GPU):
| Region | Monthly Cost (USD) | 
|---|---|
| us-central1 | $8,074.71 | 
| europe-west1 | $8,885.00 | 
| us-west2 | $9,706.48 | 
| asia-southeast1 | $10,427.89 | 
| southamerica-east1 | $12,816.56 | 
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That’s nearly a 60% price gap between the cheapest and most expensive regions.
If you’re locked to one region or cloud, you miss the chance to deploy where GPUs are both available and affordable.
Multi-cloud and cross-region setups let you:
Building your inference stack on one cloud feels convenient, until something breaks or prices spike.
Then you’re stuck.
Vendor lock-in doesn’t just limit portability; it weakens your future negotiating leverage.
If your entire workload runs on one platform, you’re forced to accept their pricing, quotas, and roadmap.
Running inference across multiple clouds removes that single point of dependency.
You can:
Think of it as diversifying your compute portfolio. It’s the same way you’d diversify financial assets.
When done right, multi-cloud, cross-region, or hybrid inference gives you a competitive advantage.
But making it work isn’t easy. For example, you need to:
Doing all this manually? That’s a full-time job for your engineering team, the time for which should be spent on innovation, not infrastructure.
That’s exactly why we built the Bento Inference Platform.
It provides a unified compute fabric, an orchestration layer that lets enterprises deploy and scale inference workloads across any GPU source, anywhere.
Here’s how it works:
With Bento, you get one inference stack that works with any GPU, in any region, on any cloud. Let your team focus on shipping faster AI products while Bento handles the infrastructure.
Still have questions?
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For large models, GPUs like NVIDIA H100 and H200, or AMD MI300X and MI355X, offer the ideal balance of compute power, memory bandwidth, and VRAM capacity for inference workloads.
For smaller models, GPUs such as NVIDIA A10, L4, or AMD MI250 provide strong price-to-performance without sacrificing quality.
Always benchmark GPUs with your own LLMs. There’s no single “best” GPU, only the one that fits your specific model size, context length, and performance goals.
Learn more about how to match GPUs with different LLMs in our handbook.
Our AI infrastructure survey showed that a significant 62.1% of respondents run inference across multiple environments. As enterprises scale, they are more likely to succeed with a hybrid strategy, combining cloud elasticity with dedicated or BYOC resources for cost control.
Focus on optimization, not just cheaper hardware. Techniques like speculative decoding, prefill–decode disaggregation, and KV-cache offloading can speed up inference and cut cost without degrading quality.
You can also route requests to cheaper regions or use multi-cloud scheduling to secure the best rates automatically.
Platforms like Bento make these optimizations easier. You can apply them out of the box and run LLM inference efficiently across any GPU source.